COMPOSTO DE GRIGNARD PDF

5 jul. 1- Dados os compostos de Grignard abaixo, forneça a nomenclatura de cada um deles: a) H3C — CH2— CH2— CH2— MgCl Cloreto de butil-. Keywords: allylic oxidation, selenium dioxide, homoallylic alcohols, Grignard adsorvido em SiO2, propicia uma rota conveniente para tais compostos. O primeiro estudo sistemático sobre os compostos organoestânicos (OTs, .. tetrassubstituído via reação de “Grignard” (brometo ou cloreto de etil, butil ou.

Author: Naramar Gardazragore
Country: Pacific Islands
Language: English (Spanish)
Genre: Career
Published (Last): 14 November 2014
Pages: 226
PDF File Size: 18.25 Mb
ePub File Size: 4.75 Mb
ISBN: 196-9-45478-639-3
Downloads: 80899
Price: Free* [*Free Regsitration Required]
Uploader: Fenrizilkree

The ether phase was grignarrd with water 30 mLthen with brine 2×30 mLdried over MgSO 4filtered and the solvent was removed under reduced pressure by rotatory evaporation.

The extracts were washed with a saturated aqueous solution of FeSO 4. The organic layer was washed with two portions of brine then dried with anhydrous MgSO 4.

Organoclorado – Wikipedia, a enciclopedia libre

Also, we developed an efficient synthesis of 2-geranylphenol derivatives via a Cu I -mediated Grignard coupling of 2-lithiophenols and geranyl substrates.

To a solution of 2-iodophenol 2. The organic layer was then dried over MgSO 4filtered compost the solvent was removed under reduced pressure. To a two-necked mL round bottom flask with 2-iodophenyl tetrahydropyranyl ether 6 3.

Then BuLi in hexane 2. Tetrahydro-2 H pyranyl ether 7 3. Kascheres on occasion of his 60 th birthday. To a solution of 10 3. Further studies on phenolic oxidation of these synthetic intermediates to achieve the synthesis of cyclic isoprenoids will be reported in due course. The mixture was stirred for 48 h. Preparation of aromatic geraniol analogues via a Cu I -mediated Grignard coupling.

Geranyl bromide 4 was necessary in the next steps and its preparation although it is commercially available was achieved after some attempts in order to optimize the conditions for getting high yield. After allowing the reaction mixture to dde ambient temperature, CuI was added followed by the addition of allylic alcohol 2.

Using lower molar quantities of SeO 2 should reduce selenium by-products, facilitating the purification of selenium-free products.

Environmental contamination for organotin compounds

The extracts were dried over MgSO 4filtered and the solvent was removed under reduced pressure by rotatory evaporation. How to cite this article. To improve the low yield that was obtained for the oxidation of 8we investigated a new route to reach 9. The reaction was cooled, a saturated solution of NH 4 Cl was added, the solutions was extracted with ether 3×50 mLdried over MgSO 4filtered and the solvent was removed under reduced pressure by rotatory evaporation.

To a stirred solution of 14 3. Nova22 Economic Entomology grignaard, 81 Preparative column chromatography was carried using silica gel 60 Merckmesh.

Carga parcial

The mixture was stirred compost ambient temperature for 8 h and then diluted with 30 mL of ether. Also, an efficient synthesis of 2-geranylphenol derivatives via a Cu I -mediated Grignard coupling of 2-lithiophenols and geranyl substrates was developed.

The same procedure as employed for the oxidation of 1 was used, starting with 7 3.

New York,p. Services on Demand Journal. Em Organotin Compounds ; Sawyer, A.

Completion of the reactions was established by TLC analysis. Acta, Geraniol was purchased from Aldrich Chem. Environmental contamination for organotin compounds. The chosen protecting groups clearly influence the oxidation process. Our target was to obtain 2-[ 2 E ,6 E -3,7-dimethylhydroxy-2,6-octadienyl]phenol 9 by optimizing the coupling of geranyl acetate derivatives with more appropriate reagent O -protected 2-iodophenol. New York,vol. However, “nontarget” organisms may be exposed, resulting in the poisoning of biological system, originating compoeto and sentencing species to extinction.

The occurrence and the ccomposto of organotin compounds OTs have been studied since a long time, due to their widespread use and deleterious effects. After the disappearance of the starting material, water 30 mL was added and the mixture was extracted with dichloromethane 2×30 mL.

Bromination of geraniol 15 with phosphorus tribromide 0. This result was still not satisfactory compoto we tried a different approach. Results and Discussion The Sharpless conditions for oxidation of geranyl acetate employs 0. Fall30 ,